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    OxyContin 40mg Tablets

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    Patient Information Leaflet 

    Your medicine is called OxyContin 20mg Tablets but will be referred to as

    OxyContin tablets throughout the leaflet.

    Read all of this leaflet carefully before you start taking this medicine

    because it contains important information for you.

    *

    Keep this leaflet. You may need to read it again.

    *

    If you have any further questions, ask your doctor or pharmacist.

    * This medicine has been prescribed for you only. Do not pass it on to

    others. It may harm them, even if their signs of illness are the same as

    yours.

    * If you get any side effects, talk to your doctor or pharmacist. This includes

    any possible side effects not listed in this leaflet. See section 4.

    What is in this leaflet

    What OxyContin tablets are and what they are used for

    What you need to know before you take OxyContin tablets

    How to take OxyContin tablets

    Possible side effects

    How to store OxyContin tablets

    Contents of the pack and other information

    What OxyContin tablets are and what they are used

    for

    These tablets have been prescribed for you by your doctor to relieve

    moderate to severe pain over a period of 12 hours. They contain the active

    ingredient oxycodone which belongs to a group of medicines called strong

    analgesics or ‘painkillers’.

    What you need to know before you take OxyContin

    tablets

    Do not take OxyContin tablets if you:

    *

    are allergic (hypersensitive) to oxycodone, or any of the other ingredients 

    of the tablets (listed in section 6’);

    *

    have breathing problems, such as severe chronic obstructive lung disease,

    severe bronchial asthma or severe respiratory depression. Your doctor will

    have told you if you have any of these conditions. Symptoms may include

    breathlessness, coughing or breathing more slowly or weakly than

    expected;

    * have a condition where the small bowel does not work properly (paralytic

    ileus), your stomach empties more slowly than it should (delayed gastric

    emptying) or you have severe pain in your abdomen.

    * have a heart problem after long-term lung disease (cor pulmonale); 

    * have moderate to severe liver problems. If you have other long-term liver

    problems you should only take these tablets if recommended by your

    doctor;

    * have ongoing problems with constipation; 

    * are under 18 years of age. 

    Warnings and precautions

    Talk to your doctor or pharmacist before taking these tablets if you:

    * are elderly or weakened;

    * have an under-active thyroid gland (hypothyroidism), as you may need a 

    lower dose

    * have myxoedema (a thyroid disorder with dryness, coldness and swelling 

    (‘puffiness’) of the skin, affecting the face and limbs;

    * have a head injury, severe headache or feel sick as this may indicate that

    the pressure in your skull is increased

    * have low blood pressure (hypotension) 

    * have low blood volume (hypovolaemia); this can happen with severe 

    external or internal bleeding, severe burns, excessive sweating, severe

    diarrhoea or vomiting;

    * have a mental disorder as a result of an infection (toxic psychosis); 

    * have inflammation of the pancreas (which causes severe pain in the

    abdomen and back)

    * have problems with your gall bladder or bile duct; 

    * have inflammatory bowel disease; 

    * have an enlarged prostate gland, which causes difficulty in passing urine 

    (in men);

    *have poor adrenal gland function (your adrenal gland is not working 

    properly which may cause symptoms including weakness, weight loss,

    dizziness, feeling or being sick), e.g. Addison’s disease;

    * have breathing problems such as severe pulmonary disease. Your doctor 

    will have told you if you have this condition. Symptoms may include

    breathlessness and coughing;

    * have kidney or liver problems;

    * have previously suffered from withdrawal symptoms such as agitation,

    anxiety, shaking or sweating, upon stopping taking alcohol or drugs;

    * are or have ever been addicted to alcohol or drugs or have a known 

    opioid dependence;

    *

    have an increased sensitivity to pain;

    * need to take increasingly higher doses of OxyContin to gain the same 

    level of pain relief (tolerance).

    If you are going to have an operation, please tell the doctor at the hospital

    that you are taking these tablets.

    Other medicines and OxyContin

    Please tell your doctor or pharmacist if you are taking, have recently taken

    or might take any other medicines, including medicines obtained without a

    prescription. If you take these tablets with some other medicines, the effect

    of these tablets or the other medicine may be changed.

    Tell your doctor or pharmacist if you are taking:


    * a type of medicine known as a monoamine oxidase inhibitor or you have 

    taken this type of medicine in the last two weeks;

    * medicines to help you sleep or stay calm (for example tranquillisers, 

    hypnotics or sedatives);

    * medicines to treat depression (such as paroxetine); 

    * medicines to treat psychiatric or mental disorders (such as phenothiazines 

    or neuroleptic drugs);

    * other strong analgesics (‘painkillers’); 

    * muscle relaxants; 

    * medicines to treat high blood pressure; 

    * quinidine (a medicine to treat a fast heart beat); 

    * cimetidine (a medicine for stomach ulcers, indigestion or heartburn); 

    * antifungal medicines (such as ketoconazole, voriconazole, itraconazole 

    and posaconazole);

    *

    antibiotics (such as clarithromycin, erythromycin or telithromycin);

    *

    medicines known as ‘protease inhibitors’ to treat HIV (e.g. boceprevir,

    ritonavir, indinavir, nelfinavir or saquinavir);

    *

    rifampicin (to treat tuberculosis);

    *

    carbamazepine (a medicine to treat seizures, fits or convulsions and

    certain pain conditions)

    *

    phenytoin (a medicine to treat seizures, fits or convulsions);

    *

    a herbal remedy called St. John’s Wort (also known as Hypericum

    perforatum);

    *

    antihistamines;

    *

    medicines to treat Parkinson’s disease.

    Also tell your doctor if you have recently been given an anaesthetic.

    Taking OxyContin tablets with food, drink and alcohol

    Drinking alcohol whilst taking OxyContin tablets may make you feel more

    sleepy or increase the risk of serious side effects such as shallow breathing

    with a risk of stopping breathing, and loss of consciousness. It is

    recommended not to drink alcohol while you’re taking OxyContin tablets.

    You should avoid drinking grapefruit juice during your treatment with this

    medicine.

    Pregnancy and breastfeeding

    Do not take these tablets if you are pregnant or breastfeeding.

    Ask your doctor or pharmacist for advice before taking any medicine.

    Driving and using machines

    These tablets may cause a number of side effects such as drowsiness which

    could affect your ability to drive or use machinery (see section 4 for a full list

    of side effects). These are usually most noticeable when you first start taking

    the tablets, or when changing to a higher dose. If you are affected you

    should not drive or use machinery.

    This medicine can affect your ability to drive as it may make you sleepy or

    dizzy

    *

    Do not drive while taking this medicine until you know how it affects you.

    *

    It is an offence to drive while you have this medicine in your body over a

    specified limit unless you have a defence (called the ‘statutory defence’).

    *

    This defence applies when:

    *

    The medicine has been prescribed to treat a medical or dental

    problem; and

    *

    You have taken it according to the instructions given by the prescriber

    and in the information provided with the medicine.

    *

    Please note that it is still an offence to drive if you are unfit because of the

    medicine (i.e. your ability to drive is being affected).

    Details regarding a new driving offence concerning driving after drugs have

    been taken in the UK may be found here:

    https://www.gov.uk/drug-driving-law

    Talk to your doctor or pharmacist if you are not sure whether it is safe for

    you to drive while taking this medicine.

    OxyContin tablets contain lactose

    These tablets contain lactose which is a form of sugar. If you have been told

    by your doctor that you have an intolerance to some sugars, contact your

    doctor before taking these tablets.

    How to take OxyContin tablets

    Always take these tablets exactly as your doctor has told you. The label on

    your medicine will tell you how many tablets to take and how often.

    Adults (over 18 years of age)

    The usual starting dose is one 10 mg tablet every 12 hours. However, your

    doctor will prescribe the dose required to treat your pain. If you find that you

    are still in pain whilst taking these tablets discuss this with your doctor.

    Do not exceed the dose recommended by your doctor. You should check

    with your doctor or pharmacist if you are not sure.

    Swallow your tablets whole with water.

    Do not crush, dissolve or chew them.

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